Real-time single-molecule imaging reveals a direct interaction between UvrC and UvrB on DNA tightropes
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چکیده
منابع مشابه
Real-time single-molecule imaging reveals a direct interaction between UvrC and UvrB on DNA tightropes
Nucleotide excision DNA repair is mechanistically conserved across all kingdoms of life. In prokaryotes, this multi-enzyme process requires six proteins: UvrA-D, DNA polymerase I and DNA ligase. To examine how UvrC locates the UvrB-DNA pre-incision complex at a site of damage, we have labeled UvrB and UvrC with different colored quantum dots and quantitatively observed their interactions with D...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2013
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkt177